Pd-catalyzed sequential distal C–H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams
Year: 2025
Type: article
Abstract: O-labeling experiment and the photophysical studies reveal distinct fluorescence in the selected macrocycles. In addition, the selected lactams exhibited biocompatibility with Vero cells and dose-dependent cytotoxicity against MCF-7 cells, highlighting their therapeutic potential. The substrate scope, functional group tolerance, selectivity, photophysical and biological properties, and the late-stage functionalization of drug molecules as well as natural product derivatives are important practical features.
Source: Chemical Science
DOI: 10.1039/d5sc08286b
Authors: Perumal Muthuraja, Prabhat Kumar Maharana, Tamilthendral Veerappan, Subhradeep Kar, Tharmalingam Punniyamurthy
Institution: Indian Institute of Technology Guwahati
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funders: Department of Science and Technology, Ministry of Science and Technology, India, Ministry of Education, India, Indian Institute of Technology Guwahati, Science and Engineering Research Board, North East Centre for Biological Sciences and Healthcare Engineering, Indian Institute of Technology Guwahati
OpenAlex ID: W4416229670