Work

A multidisciplinary approach to establishing clozapine in a patient with schizophrenia and comorbid ASD: a case report

Year: 2025

Type: article

Abstract: Background: There is substantial symptom overlap in psychosis and autism spectrum disorder (ASD) and co-morbidity is common. In addition, antipsychotic response may be moderated by the co-occurrence. Individuals with ASD may be at greater risk of some clozapine adverse effects and occasionally, its use may be contra-indicated. Case presentation: We present the case of a patient with ASD with psychosis unresponsive to multiple antipsychotics, but extra precaution was required with clozapine Conclusion: A multidisciplinary approach is required to establish clozapine in a patient with schizophrenia and ASD.

Source: BMC Psychiatry

DOI: 10.1186/s12888-025-07280-7

Authors: Madelaine Bridges, Agostina Secchi, Eromona Whiskey, Sukhi Shergill

Institutions: Kent and Medway NHS and Social Care Partnership Trust, King's College London, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Kent and Medway Medical School

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290