Left Ventricular Remodeling After Myocardial Infarction—Pathophysiology, Diagnostic Approach and Management During Cardiac Rehabilitation
Year: 2025
Type: article
Abstract: Despite the improvement in prognosis in patients with acute myocardial infarction (AMI), a significant proportion of survivors still experience heart failure (HF)-related adverse outcomes. Adverse left ventricular remodeling (LVR), which refers to a progressive dilation of left ventricular (LV) end-diastolic and end-systolic volumes, usually accompanied by a deterioration in LV systolic function, occurs frequently and underlies most cases of HF development after AMI. In this review, we discuss the current definitions of post-AMI LVR, the most appropriate imaging modalities for its detection, and the pathophysiological mechanisms by which Cardiac Rehabilitation (CR) can improve LVR-including exercise interventions, cardiovascular risk factors control, and pharmacological therapy optimization. Finally, we provide up-to-date recommendations for the follow-up and management of LVR in post-AMI patients enrolled in CR and outline future prospects on this topic.
Authors: Víctor Marcos-Garcés, Carlos Bertolín-Boronat, Héctor Merenciano-González, María Luz Martínez Mas, Josefa Inés Climent Alberola, Laura López-Bueno, Alfonso Payá Rubio, Nerea Pérez-Solé, César Ríos-Navarro, Elena de Dios, Jose Gavara, David Moratal, Jose F. Rodriguez-Palomares, Jose T. Ortiz-Pérez, Juan Sanchis, Vicente Bodi
Institutions: Hospital Clínico Universitario de Valencia, Centro de Investigación en Red en Enfermedades Cardiovasculares, INCLIVA Health Research Institute, Centro de Biomateriales e Ingeniería Tisular, Universitat Politècnica de València, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de València
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G1070254935, G1077015544, G170316319, G1716052236, G2246005815, G3139575766, G3818967781, G4604076738, G4609862051, Papel del sistema GAS6-TAM en la diferenciación fibroblástica y el remodelado ventricular tras el infarto agudo de miocardio, G6294592360, G6322232497, Obstrucción microvascular tras un infarto de miocardio. Avances hacia una cuantificación automatizada, biomarcadores basados en técnicas ómicas y una estratificación de riesgo a largo plazo personalizada, G7038334138
OpenAlex ID: W4416234146