Work

Fluorocyclopropyl-Containing Tacrine Derivatives as Potent and Selective Dual CDK2/CDK9 Inhibitors for the Treatment of Colorectal Cancer

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02328

Authors: Limeng Wu, Wenjie Liu, Wenjie Liu, Xinyue Ning, Xinyu Li, Zhiya Wang, Zhenshu Li, Yiming Qi, Jiao Xiao, Xiangbo Xu, Xudong Gao, Xinhua Liu, Yingshi Zhang, Zihua Xu, Wenwu Liu, Wenwu Liu, Yonghong Liu, Qingchun Zhao

Institutions: Shenyang Pharmaceutical University, General Hospital of Shenyang Military Region, Northeastern University, Peking University First Hospital, Northeastern University, Tsinghua University, Chinese Academy of Sciences, South China Sea Institute Of Oceanology

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Department of Education of Liaoning Province, Department of Science and Technology of Liaoning Province, Scientific Research Fund of Liaoning Provincial Education Department

Awards: G1129746059, G4385198788, G4558522942, G5364802807, G610445907, G6798047860

OpenAlex ID: W4416257157

FWCI: 1.445

Cites: 59

Cited by: 5

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