Work

Comparing Palliative Approaches for GOO in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta‐Analysis

Year: 2025

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: Gastric outlet obstruction (GOO) in locally advanced pancreatic cancer (LAPC) can be managed with endoscopic duodenal stenting (EDS), gastrojejunostomy (GJ), or EUS-guided gastroenterostomy (EUS-GE). In our meta-analysis of LAPC patients, EDS enabled quicker recovery and chemotherapy but had higher re-intervention rates, while GJ offered greater durability. Our systematic review showed EUS-GE had high success and low re-intervention in malignant GOO, though LAPC-specific data were lacking. Further comparative studies are needed to guide individualized treatment.

Source: Journal of Surgical Oncology

DOI: 10.1002/jso.70131

Authors: Asad Gul Rao, Muhammad Ahmad Nadeem, Abdul Rafeh Awan, Chase J. Wehrle, Abby Gross, Antonio Giuseppucci, Beren Berber, Syed Mohiuddin, Tyler Stevens, Hassan Siddiki, Kathryn A. Stackhouse, Samer Naffouje, Daniel Joyce, Toms Augustin, Robert Simon, R. Matthew Walsh, Rob Naples

Institutions: Dow University of Health Sciences, Cleveland Clinic

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4416258634

FWCI: 0.389

Cites: 60

Cited by: 2

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