Work

Successful treatment of a resistant invasive disseminated Fusarium infection in an immunocompetent patient

Year: 2025

Type: article

Abstract: Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies. Here, we describe a case of an immunocompetent patient with invasive disseminated fusariosis with multifocal abscess formation after major traumatic injury. We report a significant clinical improvement with clinically relevant reduction of abscesses without major treatment toxicity after treatment with fosmanogepix.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2025.100750

Authors: Frantzeska Frantzeskaki, Nikolas Stratopoulos, Sandra Elise van der Griend, Ioannis Renieris, Kostantinos Thomas, Iraklis Tsagkaris

Institutions: National and Kapodistrian University of Athens, University General Hospital Attikon, Leiden University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650