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In Vivo Pharmacokinetic Evaluation of a Gastro-retentive Triple Drug Delivery System Utilizing Natural Polymers for Enhanced Helicobacter pylori Eradication

Year: 2025

Type: article

Abstract: This study evaluates the in vivo pharmacokinetics of triple-drug gastro-retentive formulation (metronidazole- Plantago ovata seed mucilage/ clarithromycin- Abelmoschus esculentus fruit mucilage/enteric-coated pantoprazole) for Helicobacter pylori eradication, with a focus on pharmacokinetic parameters (e.g., relative bioavailability vs. conventional doses) as the true contribution. In a cross over study using six rabbits, plasma concentrations of metronidazole, clarithromycin, and pantoprazole sodium were measured via High Performance Liquid Chromatography technique, and pharmacokinetic parameters were determined. A single dose of the optimized formulation (C-8) produced optimal drug levels, with a mean Cmax of 24.36 ± 0.84 μg/mL and tmax at 6 hours. The other pharmacokinetic results were found to be satisfactory. These results suggest that the optimized formula (C-8) offers effective systemic delivery with favorable pharmacokinetics, potentially improving compliance in Helicobacter pylori treatment regimens.

Source: Bulletin of Faculty of Pharmacy Cairo University

DOI: 10.54634/2090-9101.1072

Authors: Edukulla Satheesh Kumar, Hindustan Abdul Ahad, Thirumalesh naik Sugali Banoth

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416263426

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