Life-threatening events in patients with LQT3 on and off beta-blockers: Insights from a case series
Year: 2025
Type: article
Abstract: The efficacy of beta-blocker in type 3 long QT syndrome (LQT3) remains uncertain, with conflicting results in the literature.1,2 Wilde et al1 reported benefit in women, but this was not confirmed in a French cohort.2 This discrepancy has raised concerns that confounding by indication—that is, the preferential prescription of beta-blockers to the most severely affected patients—might partly explain the apparent lack of benefit observed in some studies. To explore this hypothesis, we conducted a detailed evaluation of LQT3 patients who experienced life-threatening events (LTEs), either on or off beta-blocker therapy.
Source: Heart Rhythm O2
Institutions: Centre Hospitalier Universitaire Amiens-Picardie, Hématopoïèse et immunologie, Université de Picardie Jules Verne, Inserm, Centre Hospitalier Universitaire de Nantes, Institut du Thorax, Assistance Publique – Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, Pitié-Salpêtrière Hospital, Université Paris Cité
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,150
OpenAlex ID: W4416265773