Work

Spatially fractionated radiotherapy combined with CapeOX and bevacizumab for postoperative pulmonary metastasis from urachal carcinoma: a case report

Year: 2025

Type: article

Abstract: Urachal carcinoma is a rare and aggressive malignancy with limited treatment options, particularly in the metastatic setting. Standardized therapeutic protocols are lacking. This case report describes a 62-year-old female patient who developed pulmonary and mediastinal lymph node metastases more than four years after surgical resection of urachal carcinoma. For this case, a combined regimen of Spatially Fractionated Radiotherapy (SFRT), CapeOX (capecitabine plus oxaliplatin) chemotherapy, and bevacizumab targeted therapy was developed. The treatment course was complicated by grade 4 hematologic toxicity and radiation-induced esophagitis, both of which were successfully managed. To our knowledge, this represents the first documented application of SFRT in urachal carcinoma. Although significant tumor shrinkage was not observed, the patient achieved symptomatic relief, metabolic remission, and stable disease during follow-up.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1688215

Authors: Jian Fang, Aixin Wang, Quan Yao, Xinyi Liu, Weiyi Zhou, Jinyi Lang

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University, University of Electronic Science and Technology of China, Sichuan Cancer Hospital

Language: English

Topic: Urinary and Genital Oncology Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801