Efficiency of the Combination of Amoxicillin and Metronidazole-coated Sutures versus Triclosan-coated Sutures for Antimicrobial and Wound Healing Properties: A Research Protocol
Year: 2025
Type: article
Abstract: Introduction: Surgical Site Infections (SSIs) pose a significant challenge in various surgical procedures, including periodontal surgery. Sutures used in the oral cavity are constantly exposed to saliva, which creates a wicking effect that can impede the healing process after surgery. To address these issues, modifications to sutures are necessary. Need for the study: Coated sutures that provide local, sustained release of antibiotics may effectively prevent biofilm formation and reduce bacterial counts in the periodontal surgical area. These innovative sutures combine two drugs, which can help mitigate the wicking effect, promote faster healing, and provide effective antimicrobial action. To date, no clinical studies have evaluated such a combination in suture form, prompting the design of this animal study. Currently, triclosan-coated sutures are the only commercially available option, and the new combination sutures could serve as an alternative. There is a lack of comparative data regarding the antimicrobial and wound-healing potential of alternative antibiotic combinations, particularly in the context of periodontal surgery. Aim: To evaluate and compare the efficacy of amoxicillinand metronidazole-coated sutures versus triclosan-coated sutures in terms of antimicrobial activity and wound-healing properties. Materials and Methods: This in vitro experimental study on rabbits will be conducted in the Department of Pharmacology at the Central Preclinical Research Facility, Datta Meghe College of Pharmacy, Sawangi (Meghe), Wardha, India, from April 2025 to December 2025. The study will be carried out in two phases. In Phase I, amoxicillin-and metronidazole-coated sutures will be prepared and their drug release evaluated. In Phase II, an animal study will be conducted. The study will include 12 New Zealand rabbits of both sexes, with an average weight of 2-4 kg. The rabbits will be categorised into two interventional groups, with six rabbits in each group. Rabbits in Group I will receive 4-0 sutures coated with the combination of amoxicillin and metronidazole in the interdental area after flap elevation. In Group II, 4-0 sutures coated with triclosan will be used to assess antimicrobial activity and wound healing. For inter and intragroup comparisons, unpaired and paired t-tests will be applied, respectively. A p-value of <0.05 will be considered statistically significant.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $275
OpenAlex ID: W4416272760
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