Work

The Effect of Thyroid Function on GDF15 Levels

Year: 2025

Type: article

Abstract: Growth differentiation factor 15 (GDF15) is a stress-response cytokine, which exerts different actions in physiological and pathological conditions. Thyroid disorders are common in the general population and their role on GDF15 levels has not been sufficiently addressed. Serum levels of GDF-15 and thyroid function were assessed in a large sample from the SardiNIA cohort (n = 4413). We further collected antibodies against thyroperoxidase and anti-thyroglobulin in all participants. Thyroid function correlated with GDF15. Specifically, after adjusting for covariates, thyrotropin had a positive association with GDF15, while free thyroxine was negatively correlated. We also found that subjects with circulating antibodies against thyroperoxidase had lower GDF15 levels. The reduced level of the thyroid hormone can cause a decreased metabolic activity and higher cell stress response, which, in turn, increases the production of GDF-15 as a defense mechanism. The association between antibodies against thyroperoxidase and GDF15 deserves additional study to elucidate the pathophysiologic relationship.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms262211073

Authors: Nicia I. Profili, Edoardo Fiorillo, Valeria Orrù, Francesco Cucca, Alessandro P. Delitala

Institutions: University of Sassari, National Research Council

Language: English

Topic: GDF15 and Related Biomarkers

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499