Work

Clinical spectrum and genotypes of children with alpha-thalassemia in northeastern, Thailand

Year: 2025

Type: article

Abstract: Background: Alpha-thalassemia is a common inherited hemoglobin disorder. Hemoglobin H (Hb H) disease, a form of alpha-thalassemia caused by the inactivation of three α-globin genes through deletional or non-deletional mutations, presents with a broad clinical spectrum, ranging from non-transfusion-dependent thalassemia (NTDT) to transfusion-dependent thalassemia (TDT). Objective: To characterize the clinical manifestations and genetic diversity of alpha-thalassemia in pediatric patients.

Source: Mediterranean Journal of Hematology and Infectious Diseases

DOI: 10.4084/mjhid.2025.081

Authors: Patcharee Komvilaisak, Nattakarn Sangkha, Arunee Jetsrisuparp, Kunanya Suwannaying, Goonnapa Fucharoen, Napat Laoaroon

Institution: Khon Kaen University

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $647