Work

Pediatric heart-kidney transplantation

Year: 2025

Type: article

Abstract: Heart transplantation is regarded as the definitive treatment for advanced pediatric heart failure. However, concomitant kidney dysfunction often complicates candidate selection for isolated heart transplantation. Prolonged venous congestion, nephrotoxic exposures, and recurrent episodes of acute kidney injury can result in varying degrees of renal impairment. Differentiating between reversible kidney injury secondary to cardiorenal syndrome and irreversible intrinsic renal disease remains a major challenge. Pediatric heart-kidney transplantation has shown survival benefits for patients with end-stage heart failure requiring chronic dialysis, yet its role in patients with less severe renal dysfunction is less clearly defined. This review summarizes the current evidence on patient selection, perioperative and post-transplant management, and ethical considerations for pediatric heart-kidney transplantation.

Source: JHLT Open

DOI: 10.1016/j.jhlto.2025.100393

Authors: Swati Choudhry, Kriti Puri, Vikas R. Dharnidharka

Institutions: Baylor College of Medicine, Texas Children's Hospital, Rutgers, The State University of New Jersey, The Bristol-Myers Squibb Children's Hospital, Rutgers Health

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500