Work

Trifluoromethanesulfonic Acid‐Promoted Esterification of Unactivated Tertiary Amides with Tetrahydrofurans and Potassium Halides to Access Haloalkyl Esters

Year: 2025

Type: article

Abstract: Herein, we report a trifluoromethanesulfonic acid‐promoted esterification reaction of unactivated N,N ‐dialkyl amides with tetrahydrofurans and potassium halides. One‐pot construction of carbon‐halogen and carbon‐oxygen bonds was achieved under transition‐metal‐free condition to furnish a wide range of haloalkyl esters in 22 – 82% yields. Preliminary mechanistic studies imply that this esterification possibly proceeds through the cross‐coupling of in situ generated acyl halides and 4‐halobutanols.

Source: ChemistrySelect

DOI: 10.1002/slct.202505934

Authors: Yueyue Fan, Dongran Song, Yongbing Liu, Fang‐Fang Feng

Institution: Hebei Normal University

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Hebei Normal University, Natural Science Foundation of Hebei Province, Chinese University of Hong Kong, Hebei Provincial Department of Bureau of Science and Technology

Awards: G198357249, G7605423039