Work

SMARCA4/BRG1-deficient NSCLC: a case report and literature review

Year: 2025

Type: article

Abstract: Patients with non-small cell lung cancer (NSCLC) deficient in SMARCA4 (SMARCA4-dNSCLC) are commonly diagnosed at advanced stages with a poor prognosis. Although immune checkpoint inhibitors (ICIs) combined with platinum-based chemotherapy regimens are widely used, their efficacy in SMARCA4-dNSCLC patients remains suboptimal. Herein, we present the case of a SMARCA4 dNSCLC patient treated at Yijishan Hospital on January 18, 2023. Following our comprehensive treatment, our patient's general condition and quality of life (QOL) have remained satisfactory, and there has been no disease progression to date.

Source: Journal of the Pakistan Medical Association

DOI: 10.47391/jpma.22492

Authors: He Zhang, Xiong-wen Tu, Yu-qing Wei, Zheng-zheng Ni, Liang Cheng, Juan Wu

Institutions: First Affiliated Hospital of Wannan Medical College, Wannan Medical College

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650