Year: 2025
Type: article
Abstract: Dysembryoblastic neuroepithelial tumour (DNET) are rare, benign WHO grade I glioneuronal tumours that mainly affect children and adolescents, commonly presenting with drug-resistant seizures. They typically arise in the temporal lobe cortex and show characteristic MRI features of cortical based, multicystic lesions without significant oedema or mass effect. Histologically, DNETs have a multinodular architecture with glioneuronal components and are classified into simple, complex, and nonspecific subtypes. Gross total resection is the treatment of choice, offering excellent seizure control and prognosis, while incomplete resection increases the risk of recurrence. Though malignant transformation is uncommon, reported cases highlight the importance of long-term follow-up. Early diagnosis, complete excision, and sustained surveillance are essential to achieving favourable outcomes.
DOI: 10.47391/jpma.25-80
Authors: Noman Ahmed, Muhammad Shahzad Shamim
Institution: Aga Khan University Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $650
OpenAlex ID: W4416293209