Year: 2025
Type: article
Abstract: groups are sequentially converted into trifluoromethyl radicals, enabling high-yielding transformations under mild conditions. The protocol exhibits excellent functional group tolerance and is applicable to the late-stage trifluoromethylation of pharmaceuticals, amino acids, and nucleosides. Mechanistic studies support a photoinitiated radical pathway and reveal the full utilization of the Cu(iii) species. The results presented advance the use of copper-mediated strategies for the sustainable incorporation of fluorine into complex molecules.
Source: Chemical Science
DOI: 10.1039/d5sc07405c
Authors: Petr Pospíšil, Vladimir Motornov, Ondřej Michal, Lucie Šálková, Soňa Boháčová, Tomáš Slanina, Ján Tarábek, Blanka Klepetářová, Petr Beier
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
Awards: G1216960824, G5093457562
OpenAlex ID: W4416300614