Work

Necrotizing Autoimmune Myopathy With HMGCR Antibodies: An Uncommon Presentation of Autoimmune Myositis in a Middle-Aged Woman Without Known Malignancy, Connective Tissue Disorder, or Statin Therapy

Year: 2025

Type: article

Abstract: We report an uncommon presentation of necrotizing autoimmune myopathy (NAM) associated with anti-HMGCR antibodies in a middle-aged woman who lacked typical risk factors, including statin use, malignancy, or connective tissue disease. The patient presented with muscle weakness, markedly elevated creatine kinase levels, and muscle biopsy findings consistent with necrosis. Diagnosis of NAM was confirmed through the detection of anti-HMGCR antibodies. Despite the initiation of corticosteroid therapy, the condition progressed rapidly, highlighting the aggressive nature of this form of autoimmune myositis. This case underscores the importance of considering NAM in the differential diagnosis of idiopathic myopathy, even in the absence of common predisposing factors, and emphasizes the need for early detection and individualized treatment strategies.

Source: Cureus

DOI: 10.7759/cureus.97009

Authors: Manoj Kumar Mahadevaswamy Susheela, Rekha Kethohalli Shivamurthy, Sathia Narayanan Mannath, Stephen Proctor, Cornelius James Fernandez

Institutions: University Hospitals of Derby and Burton NHS Foundation Trust, United Lincolnshire Hospitals NHS Trust

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416301788