One‐Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: The lingering effects of COVID-19 may impair survivors' long-term health-related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle- and low-income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when Omicron was the predominant variant. Adult COVID-19 survivors were followed for 12 months via telephone interviews. The primary outcome was HRQoL at 12 months, assessed using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L; range -0.17 to 1.0). All-cause mortality was a secondary outcome. Among 649 participants (47.9% women; median age 71 years), the median EQ-5D-3L utility score at 12 months was 0.69 (IQR 0.41-0.80), and survival was 86.6%. Factors associated with lower HRQoL included female sex, age ≥ 60 years, Charlson comorbidity index ≥ 1, and need for respiratory support. Mortality was associated with age ≥ 60 years (HR 2.81), CCI ≥ 2 (HR 2.17), need for low-flow oxygen therapy (HR 2.03), and BMI ≥ 25 kg/m² (HR 0.58). One year after hospitalization, Omicron survivors in Brazil showed impaired HRQoL and high mortality. Older age, comorbidities, and need for oxygen therapy were linked to worse outcomes. Long-term support strategies are needed for these vulnerable populations.
Source: Journal of Medical Virology
DOI: 10.1002/jmv.70687
Authors: Geraldine Trott, Marciane Maria Rover, Fernando Luis Scolari, Mariana Motta Dias da Silva, Denise de Souza, Rosa da Rosa Minho dos Santos, Raíne Fogliati De Carli, Emelyn de Souza Roldão, Gabriela Soares Rech, Duane Mocellin, Jennifer Menna Barreto de Souza, Aline Paula Miozzo, Carolina Rothmann Itaqui, Gabrielle Nunes da Silva, Sergio Renato da Rosa Decker, Erica Neves Leite, Carlos Delmar do Amaral Ferreira, Lucas Gobetti da Luz, Gabriel Beilfuss Rieth, Lucas Tramujas, Fernando Azevedo Medrado, Bruna Fornazieri Piotto, Gizelle Fernanda Oliveira Silva, Josafá Ferreira Chaves, Saionara Cristina Francisco, Precil Diego Miranda de Menezes Neves, Victor Augusto Hamamoto Sato, Viviane Cordeiro Veiga, Kaique Lima Martins, Cláudio Dornas de Oliveira, Sabrina Gomes dos Santos, Juliana Cardozo Fernandes, Thiago Costa Lisboa, Vivian Menezes Irineu, Mauricio Antonio Pompilio, Adriana de Oliveira França, Aline Coletto Jaccottet, Juliana Carvalho Schleder, Vinicius Ortigosa Nogueira, Vandack Nobre, Daniel Souto Silveira, Cézar Eumann Mesas, Diego Miltersteiner, Emanuelle Toledo Ortiz, Fernando Gioppo Blauth, Luciane Maria Facchi, Milena Soriano Marcolino, Ana Carolina Peçanha Antonio, Paulo R. Schvartzman, Bruna Brandão Barreto, Caroline Cabral Robinson, Maicon Falavigna, Carisi Anne Polanczyk, Luiz Antonio Nasi, Regis Goulart Rosa, Post‐Covid Brasil 1 Group Autorship
Institutions: Hospital Moinhos de Vento, Universidade Federal do Rio Grande do Sul, Hospital Alemão Oswaldo Cruz, Beneficência Portuguesa de São Paulo, Grupo Santa Casa de Belo Horizonte, Hospital Ernesto Dornelles, Hospital de Clínicas de Porto Alegre, Fundação Universitária de Cardiologia, Universidade Estadual de Ponta Grossa, Universidade Federal de Minas Gerais, Hospital das Clínicas da Universidade Federal de Minas Gerais
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,730
Funder: Ministério da Saúde
OpenAlex ID: W4416309147