Work

Histopathologic effect and immunomodulatory of Indigofera oblongifolia with silver nanoparticles against splenic injury by Plasmodium chabaudi infection in mice

Year: 2025

Type: article

Abstract: Malaria, a globally prevalent disease caused by Plasmodium species, significantly impacts the immune system, particularly affecting splenic function. This study investigates the therapeutic potential of Indigofera oblongifolia leaf extracts (IOLE) with silver nanoparticles (AgNPs) against Plasmodium chabaudi -induced splenic damage in a female C57BL/6 mice model. Fifty female mice were infected with P. chabaudi and subsequently treated with IOLE AgNPs or chloroquine phosphate. Histopathological and immunohistochemical analyses revealed that IOLE AgNPs effectively restored splenic architecture, reduced inflammatory markers, and improved immune responses compared to the control and chloroquine-treated groups. These findings suggest that IOLE AgNPs may offer a novel therapeutic approach to mitigate splenic dysfunction associated with malaria and provide comparative analysis between established therapies like chloroquine and innovative combination of traditional medical plant and modern nano technology.

Source: Innate Immunity

DOI: 10.1177/17534259251396376

Authors: Mutee Murshed, Jameel Al-Tamimi, Hind Alzaylaee, Hani Ahmeda, Saleh Al-Quraishy

Institutions: King Saud University, Princess Nourah bint Abdulrahman University, Nanchang University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650