Year: 2025
Type: article
Abstract: Peptides are emerging as a preferred targeting agent for many radiopharmaceutical targets due to several favourable characteristics, including high tissue penetration and target specificity. Among them, disulfide-rich peptides stand out for their exceptional intrinsic stability, making them particularly well-suited for further development in this field – yet they remain underexplored. This review highlights examples where disulfide-rich peptides have been used in radiopharmaceuticals for imaging and therapy. We compare them to recently approved peptide radiopharmaceuticals to provide context and support for the broader use of disulfide-rich peptides for targeted delivery of radiation. Future directions are also discussed, including how emerging technologies can be applied to the discovery of new disulfide-rich peptide radiopharmaceuticals.
Source: Australian Journal of Chemistry
DOI: 10.1071/ch25096
Authors: Joshua J. Dilly, Benjamin Savage, Conan K. Wang
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Developing novel peptide tracers for improving immunotherapy outcomes, A molecular platform for design and production of next-generation peptides, ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals, Peptides and Proteins for Fighting Pests and Protecting the Environment
OpenAlex ID: W4416329590