Femtolitre Volume cryoEM Sample Preparation Using a Force‐Sensitive Microfluidic Cantilever (Adv. Mater. Technol. 22/2025)
Year: 2025
Type: article
Abstract: Force-Sensitive Microfluidic Cantilevers This image presents a novel method for cryoEM sample preparation using a force-sensitive microfluidic AFM cantilever. It enables femtolitre-scale extraction of subcellular material from individual cells and precise dispensing onto cryoEM grids. The technique allows high-resolution imaging of biological structures in native context, addressing limitations of conventional methods and offering new possibilities for cellular ultrastructure studies. More information can be found in the Research Article by Arjen J. Jakobi, Murali Krishna Ghatkesar, Andreas Engel, and co-workers (10.1002/admt.202501333).
Source: Advanced Materials Technologies
DOI: 10.1002/admt.70242
Authors: Vijayendra Shastri, Joachim Pronk, Eleonoor Verlinden, Daniel Torres González, Edin Sarajlic, Paul Laeven, Wiel Evers, Patrick Frederix, Urs Staufer, Arjen J. Jakobi, Murali Krishna Ghatkesar, Andreas Engel
Institutions: Delft University of Technology, Maastricht University
Language: English
Subfield: Structural Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4416340118
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