Work

Computational Fluid Dynamics in Predicting Renal Malperfusion After Aortic Dissection Repair

Year: 2025

Type: article

Abstract: BACKGROUND: Renal atrophy following aortic repair is difficult to be identified through renal function biochemical measures due to compensation. Computational fluid dynamics (CFD) analysis is a promising approach for identifying anomalies of renal blood supply, which is related to renal atrophy. CASE SUMMARY: This study reports 3 patients who underwent renal atrophy after aortic repair during follow-up. The hemodynamics of renal arteries in each case was analyzed through employing the CFD method. The pressure ratio (PR; renal artery-to-aorta) measurements revealed significantly lower values on the atrophic side of the renal artery when comparing to the nonatrophic side. DISCUSSION: PR is promising to serve as an early quantitative indicator, with persistent depression prior to obvious morphological atrophy. Serial CFD-based PR assessments show promise in predicting the risk of renal atrophy and facilitating earlier intervention. TAKE-HOME MESSAGE: Patient-specific CFD simulations based on computed tomography angiography offer hemodynamic profiling to detect perfusion compromise in the preclinical phases.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.106060