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A Positive Relationship Exists between the Triglyceride to Glucose Index and Waist-to-Hip Ratio with Stroke Risk in Middle-Aged and Older Chinese

Year: 2025

Type: article

Abstract: This study determined the association between the triglyceride-glucose (TyG) index–waist-to-hip ratio (TyG–WHR) and stroke. Data from the China Health and Retirement Longitudinal Study (CHARLS) were utilized from baseline in 2011 to the wave six follow-up in 2020. The CHARLS cohort was assembled using a multistage probability sampling technique. Participants were comprehensively assessed through standardized questionnaires with face-to-face interviews. A total of 4,911 patients with 2,338 males (47.6%) and 2,573 females (52.4%) were included in this analysis. A significant association between the TyG–WHR and the risk of stroke was identified utilizing a Cox proportional hazards regression model with cubic spline functions that were characterized by a nonlinear relationship. The analysis determined a threshold for the TyG–WHR at 4.635. The association between the TyG–WHR and stroke was not significant [hazard ratio (HR), 0.813; 95% CI, 0.662–0.999; p = 0.049] to the left of the threshold. The association was statistically significant (HR, 1.271; 95% CI, 1.131–1.429; p < 0.001) to the right of the threshold. The current study demonstrated a positive and nonlinear association between the TyG–WHR and stroke risk among middle-aged and elderly Chinese populations. When the TyG–WHR exceeded 4.635, there was a statistically significant positive correlation with the occurrence of stroke. Clinically, reducing the TyG–WHR, especially <4.635, may reduce the risk of stroke.

Source: eNeuro

DOI: 10.1523/eneuro.0264-25.2025