Standardization and Toxicity Study of Kushta Marjan Sada
Year: 2025
Type: article
Abstract: Background: Kushta (calx) is a blend of metals, metallic oxides, nonmetals, and their compounds, minerals, and some plant-origin drugs. It is the finest Unani dosage form. Despite being distinguished for therapeutic use, very few kushta (s) have been standardized on scientific parameters and evaluated for their toxicity. Aims and Objectives: This study is strategized for the standardization and toxicity study of Kushta Marjan Sada (KMS), a Unani pharmacopeial preparation. Materials and Methods: Classical, conventional, and analytical methods have been used for standardization. Acute and sub-acute toxicity studies have been carried out according to OECD guidelines (423). The parameters for standardization included classical tests, such as luster test, fineness test, floating test, curd test, lemon test, and wall stick test. Conventional tests included moisture content, pH, quantitative elemental analysis, and powder characterization. For the toxicity study, body weight, food intake, organ weight, skin changes, and motility as general observation and hematology, LFT, RFT, and histopathology as specific parameters were taken. Results: Some heavy metals were detected, but within the permissible limit. The drug seemed to be safe; however, a chronic toxicity study is needed to establish complete safety. Conclusion: No data on the standardization and toxicity of KMS are available. Hence, our findings may be considered as a standard for future reference.
Authors: Shamim Ahmad, Abdul Wadud, Najeeb Jahan, Mohd Afsahul Kalam, Saif Javed
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4416363003