Work

First case report of lorlatinib in the treatment of ALK-fusion-positive lung adenocarcinoma with ovarian metastasis: Clinicopathological and molecular characterization

Year: 2025

Type: article

Abstract: BACKGROUND: Ovarian metastasis from anaplastic lymphoma kinase (ALK)-positive lung adenocarcinoma is exceedingly rare. Reporting such cases is vital for understanding its clinical management. PATIENT CONCERNS: A 49-year-old woman presented with a 10-day history of amenorrhea and lower abdominal pain. DIAGNOSES: Imaging revealed bilateral ovarian masses and liver nodules. Liver biopsy and genetic testing confirmed the diagnosis of stage IV EML4-ALK fusion-positive lung adenocarcinoma with ovarian and hepatic metastases. INTERVENTIONS: First-line treatment with the third-generation ALK inhibitor lorlatinib (100 mg, once daily) was initiated. OUTCOMES: The patient achieved a partial response with significant lesion regression and normalized tumor markers, sustained for over 12 months. No severe adverse events occurred. LESSONS: This case underscores the importance of molecular profiling in diagnosing metastatic tumors and confirms lorlatinib as a highly effective first-line therapy for ALK-positive non-small cell lung cancer with atypical metastases.

Source: Medicine

DOI: 10.1097/md.0000000000045222