Work

Inherently chiral homo-heteracalixarenes: design and synthesis via an enantioselective intramolecular Sonogashira cross-coupling reaction

Year: 2025

Type: article

Abstract: an intramolecular Sonogashira cross-coupling reaction affords the 17- or 18-membered chiral cyclophanes in modest yields with up to 90% ee. The strained bent alkyne moiety within the macrocycle provides a key reactive handle for macrocycle-to-macrocycle derivatization. Further, we showed the unique macrocyclic structures and demonstrated interesting chiroptical properties of the obtained enantioenriched homo-calixarenes and their derivatives.

Source: Chemical Science

DOI: 10.1039/d5sc05923b

Authors: Y.-F. Jiang, Y. Zhang, S. Tong, J. Zhu, M.-X. Wang

Institutions: Tsinghua University, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: École Polytechnique Fédérale de Lausanne, National Natural Science Foundation of China, Tsinghua University

Awards: G1698011894, G2376201943, G2705051328