Diffuse Large B‐Cell Lymphoma Combined With Paroxysmal Nocturnal Hemoglobinuria: A Rare Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Diffuse large B-cell lymphoma (DLBCL) is a common hematological malignancy, and some patients may present with autoimmune hemolytic anemia (AIHA). However, the coexistence of DLBCL and paroxysmal nocturnal hemoglobinuria (PNH) is rare. PNH patients may develop myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), but lymphomas are rarely seen. Here, we focus on a 46-year-old female patient afflicted with PNH for 3 years before being diagnosed with DLBCL. Different from DLBCL accompanied by AIHA, this case did not benefit from the R-CHOP regimen. This case demonstrates that PNH can coexist with malignant lymphoma, which is a rare finding. It also enhances our understanding of the clinical management of DLBCL coexisting with PNH.
Source: Clinical Case Reports
DOI: 10.1002/ccr3.71394
Authors: Zhen zhen Liu, Da lin Di, An hua Feng, Jie Yu, Hai ying Wang, Lili Qin
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,820
OpenAlex ID: W4416381820