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Case Report: A rare case of gallbladder carcinosarcoma with osteosarcomatous differentiation

Year: 2025

Type: article

Abstract: Gallbladder carcinosarcoma (GBCS) is indeed an exceptionally rare and aggressive malignancy, accounting for less than 1% of all primary gallbladder tumors. This tumor is characterized by the presence of both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a unique and diagnostically challenging entity. Herein, we report a case of a 71-year-old female patient who presented with a one-year history of vague epigastric pain. AFP levels were markedly elevated. Preoperative imaging revealed gallbladder enlargement with heterogeneous contrast enhancement, raising suspicion of malignancy. The patient subsequently underwent radical cholecystectomy, and postoperative histopathological examination confirmed the diagnosis of GBCS with osteosarcomatous differentiation. The patient has since completed her first cycle of chemotherapy. Even with radical resection and adjuvant chemotherapy, GBCS carries a grave prognosis. Heightened clinical suspicion, thorough imaging assessment, and confirmatory histopathological biopsy are essential for accurate preoperative diagnosis. Surgical optimization and personalized treatment strategies remain critical to improving outcomes.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1692825

Authors: Jiajun Shi, Miao Shen, Jie Yao, Xiangxiang Shen, Zhengrong Su

Institutions: Sir Run Run Shaw Hospital, Zhejiang University

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801