Work

Combine effects of robotic assisted gait training with transcranial magnetic stimulation on gait metrics and balance in stroke patients: a pilot randomized control

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background and objective Stroke often causes gait and balance impairments due to disrupted neural control. While robotic-assisted gait training (RAGT) improves motor function, combining it with low-frequency transcranial magnetic stimulation (LF-rTMS) may enhance neuroplasticity and recovery. This pilot RCT investigates the feasibility and synergistic effects of RAGT + LF-rTMS on gait and balance in stroke patients. Materials and methods This pilot RCT included 21 stroke patients randomized into three groups: RAGT + active LF-rTMS, RAGT + sham rTMS, and control (standard physiotherapy). RAGT used an exoskeleton with adjustable speed (0.8–1.8 km/h) and body-weight support (40–60%). LF-rTMS (1 Hz, 80% RMT) targeted the unaffected hemisphere’s M1. Outcomes included 3D gait analysis (spatiotemporal metrics), dynamic balance (COP sway), and clinical scales (FMA-LE, BBS, MMT). Results The RAGT+TMS group demonstrated more improvements in balance (BBS: Δ22.58 vs. Δ15.40 in RAGT+sham TMS; p = 0.05) and motor function (FMA: Δ5.86 vs. Δ1.61; p = 0.04) compared to other groups. Gait analysis revealed significant left step length increases in RAGT+TMS ( Δ 6.86 cm, p = 0.04), while balance metrics showed reduced postural sway (oscillation length: Δ − 25.01 cm, p = 0.04). All groups improved temporally ( p < 0.01), but RAGT+TMS yielded synergistic enhancements in functional recovery. Conclusion This study demonstrates that combined RAGT and LF-rTMS significantly enhances post-stroke motor recovery, yielding clinically superior improvements in balance (BBS), gait symmetry, and postural control compared to RAGT alone or conventional therapy. The synergistic effects highlight TMS’s potential to augment neuroplasticity when paired with robotic training. While further large-scale trials are needed, these findings support integrating dual-modality approaches for comprehensive stroke rehabilitation. Clinical trial registration https://www.chictr.org.cn/indexEN.html , ChiCTR2200066978.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1655409

Authors: Abdullah Jehangir, Irfan Ahmad, Yali Feng, Wang Wei Juan, Ting Chen, Ying Yin

Institutions: Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University

Language: English

Topic: Stroke Rehabilitation and Recovery

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801