An organolutetium nanosensitizer synergizes with PARP inhibition to unleash STING-mediated immunity for low-dose radioimmunotherapy
Year: 2025
Type: article
Abstract: This theranostic strategy suppressed primary and distant (abscopal) tumors, prevented recurrence, and established durable immune memory with low-dose irradiation. Our findings present a clinically translatable approach that combines a nanosensitizer with PARP inhibition to turn immunologically "cold" tumors into "hot" ones, thereby enhancing the efficacy of low-dose radioimmunotherapy while limiting systemic toxicity.
Source: Theranostics
DOI: 10.7150/thno.124034
Authors: Bingchun Zeng, Kai Ling, Qingpeng Yuan, Zeyang Chen, Guangrong Zhang, Wenyue Kang, Xuanjun Zheng, Chuanghong Liao, Youqing Mai, Zhongjie Huang, Ruibin Huang, Tiantian Zhai, Hongyan Jiang
Institutions: Shantou University, Cancer Hospital of Shantou University Medical College, Shantou University Medical College, First Affiliated Hospital of Shantou University Medical College, Shenzhen Maternity and Child Healthcare Hospital, Second Affiliated Hospital of Shantou University Medical College
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4416386730