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Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk

Year: 2025

Type: article

Abstract: Impairment of mitochondrial quality control promotes atrial inflammation and remodeling in diabetes through mtDNA-induced cGAS-STING activation and cardiomyocyte-macrophage communication. Targeting this pathway may offer a novel strategy for AF management in metabolically compromised hearts.

Source: Theranostics

DOI: 10.7150/thno.124140

Authors: Shan Meng, Jinfeng Duan, Jikai Zhao, Zijun Zhou, Boxuan Sun, Yinli Xu, Tao Huang, Tao Hong, Xin Chen, Tong Su, Liming Yu, Huishan Wang

Institutions: Sun Yat-sen University, Sixth Affiliated Hospital of Sun Yat-sen University, General Hospital of Shenyang Military Region, China Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Northeastern University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4416386744

FWCI: 4.293

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Cited by: 17

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