Work

H3K27 Acetylation-driven IGF2BP2 Mutates during the Aging of MSCs, thereby Influencing Osteogenic Differentiation and Bone Aging

Year: 2025

Type: article

Abstract: and enhanced bone regeneration in aged mice by improving bone mineral density and trabecular microstructure. These findings establish the H3K27ac-IGF2BP2-HMGA1 axis as a central regulator of bone aging and propose CWI1-2 as a promising therapeutic agent for age-related osteoporosis.

Source: International Journal of Biological Sciences

DOI: 10.7150/ijbs.122708

Authors: Zimo Zhou, Kai Kang, Heran Wang, Boya Wen, Da Liu

Institutions: Sheng Jing Hospital, China Medical University, University of South China

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337