SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy
Year: 2025
Type: article
Abstract: , while SIRT6 was inhibited. In conclusion, our findings provide compelling evidence that SIRT6 establishes a network linking nuclear and mitochondrial transcription through the regulation of TFAM, identifying TFAM as a potential therapeutic target for cancer.
DOI: 10.7150/ijbs.120007
Authors: Meimei Jiang, Jiehan Li, Ning Ding, Guiyun Jia, Siming Wu, Nannan Liu, Ying Kang, Ge Zhang, Jiawei Wu, Lingling Zhang, Yingjie Zhang
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4416386824