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Laser-assisted photodynamic therapy for oral verrucous leukoplakia and chronic hyperplastic candidosis: a case report

Year: 2025

Type: article

Abstract: Significance To report a case of laser-asstisted photodynamic therapy for the treatment of oral verrucous leukoplakia and chronic hyperplastic candidosis. Approach Oral examination revealed large white plaques on the bilateral cheeks and transitional sulci, which were elevated above the mucosal surface. Histopathological examination showed that the left cheek was verrucous leukoplakia, and the right transitional sulcus was squamous epithelial hyperpapillary hyperplasia. PAS staining showed Candida hyphae infiltrating the epithelium. The final diagnosis was oral verrucous leukoplakia and chronic hyperplastic candidiasis. Finally, we used medication to control fungal infection and eliminated lesions through laser-asstisted photodynamic therapy. Results Patient's oral lesions achieved good therapeutic effects through laser-assisted photodynamic therapy. Conclusions Laser-assisted photodynamic therapy is an effective method for treating oral verrucous leukoplakia and chronic hyperplastic candidosis.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104912