Work

Molecular Design Strategy for Iridium(Ⅲ)-based Photosensitizers to Enhance the Phototoxicity Index and Efficacy of Photodynamic Therapy

Year: 2025

Type: article

Abstract: In photodynamic therapy (PDT), the phototoxicity index (PI) is crucial for evaluating photosensitizer (PS) efficiency, with dark toxicity lowering PI and increasing side effects. Ir(III)-based PSs effectively generate ROS, but some exhibit high dark toxicity, reducing PDT efficacy. Here, we propose a molecular design strategy to mitigate dark toxicity and enhance phototoxicity by modulating charge and incorporating organelle-targeting groups. Our results show that neutrally charged PSs exhibit lower dark toxicity than positively charged PSs, while organelle-targeting modifications enhance phototoxicity. This study highlights the importance of optimizing molecular charge and targeting properties to maximize PDT effectiveness.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105083

Authors: Gwangsu Yoon, Mingyu Park, Tae-Hyuk Kwon

Institution: Ulsan National Institute of Science and Technology

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610