Work

Nrf2 reduces psoriasis skin damage by inhibiting NLRP3

Year: 2025

Type: article

Abstract: Significance Traditional Chinese medicine (TCM) is effective in treating psoriasis. However, in rare cases, TCM treatment exacerbates skin lesions. In this study, we aim to address the possibility that the MTX ingredient in TCM might increase the risk of cutaneous ulceration in psoriasis patients. Approach We retrospectively analyzed 5 patients who developed painful skin ulcers at primary psoriasis lesions after oral TCM treatment. Blood cell counts, liver function, serum MTX concentration, and ABCB1 gene polymorphisms were assessed, and ulcer biopsies were performed. Results Two presented hemocytopenia and two abnormal liver function. Two cases showed serum MTX concentration of 0.03-0.11 μmol/L (<0.1mol/L 72h after MTX intaking). The ABCB1genotypes AA and AG were detected in two different patients. Lesions healed completely within two weeks after oral folic acid in 3 patients; ulcers improved in the remaining 2 patients after discontinuing TCM. Conclusions MTX-containing TCM can incur skin ulceration in rare cases of psoriasis patients.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105160

Authors: Yunhong Zheng, Yinzi Dubai, Ruizhe Wang, Suju Luo

Institution: Tianjin Medical University General Hospital

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610