Work

ALA-PDT combined with Alpha Hydroxy Acids in the treatment of disseminated superficial actinic porokeratosis: a case report

Year: 2025

Type: article

Abstract: A 45-year-old female patient complained of brown patches on her arms and thighs. The lesion had been present for 20 years, worsened after sun exposure. The patient was treated with local corticosteroids, oral antihistamines, and acitretin capsules, but there was no clinical improvement. Physical examination revealed hypertrophic brown plaques in the limbs, with bulging around and depressed center. Punch biopsies of the lesions' hyperkeratotic margins found columns of parakeratosis suggestive of cornoid lamellae. Based on the clinical and histopathological findings, the diagnosis was made of disseminated superficial actinic porokeratosis. ALA-PDT (concentration 10%-20% for 4 hours) was initiated at 2-week intervals. After 7 photodynamic therapies, the skin lesions were basically flattened and and pigmentation remained. She was further treated with 50% alpha hydroxy acids once a month. After 2 fruit acid peeling, the pigmentation was relieved. PDT combined with alpha hydroxy acids has significant efficacy on disseminated superficial actinic porokeratosis.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105152

Authors: Shuting Chen, Yichuan Gan, Wei Li

Institutions: Guangzhou Institute of Dermatology, Guangzhou Medical University

Language: English

Topic: Genetic and rare skin diseases.

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610