Work

Photodynamic therapy using talaporfin sodium for malignant meningioma

Year: 2025

Type: article

Abstract: Introduction Grade 2 and 3 meningiomas recur early and there is no effective post-treatment other than radiation. Photodynamic therapy (PDT) using talaporfin sodium selectively kills tumor cells and improves local tumor control. In this article, we present our treatment strategy with PDT for malignant meningioma. Methods 14 patients with grade 2 or 3 meningiomas treated using PDT were analyzed. PDT was performed mainly on the adherent dura mater, but also on the parenchymal side of the brain when the border with the normal brain was unclear. Result There were no adverse events due to PDT. Regardless of grade, the patients who had a history of radiotherapy prior to treatment tend to relapse as early as one year. On the other hand, in the absence of a history of radiotherapy, recurrence is often absent for more than 1.5 years. Conclusion PDT for malignant meningiomas is effective in patients with no prior radiotherapy.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104978

Authors: Shinjiro Fukami, Kenta Nagai, Jiro Akimoto, Michihiro Kohno

Institutions: Tokyo Medical University, Kohsei Chuo General Hospital

Language: English

Topic: Meningioma and schwannoma management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610