Work

Facial Port Wine Stain Distribution and Clinical Manifestations of Sturge-Weber Syndrome, Hematoporphyrin monomethyl ether Photodynamic Therapy Effectiveness: A Retrospective Study

Year: 2025

Type: article

Abstract: Significance Sturge-Weber syndrome (SWS) is a rare, congenital disease which frequently characterized by facial port wine stain (PWS) and capillary-venous malformation of the leptomeninges and eye. The aim of this article is to present the clinical manifestations and facial lesions distribution of this syndrome and to assess the efficacy and safety of HMME PDT for treating facial PWS in SWS patients. Approach Clinical data were collected from 52 cases with confirmed SWS, who were treated with two sessions of HMME mediated PDT. Results Fair to excellent clearance was achieved in 59.6%(n = 31) SWS patients after two sessions of HMME mediated PDT. The side effects after treatment mainly displayed with short-term pain, edema, pruritus, crust, hyperpigmentation. No severe adverse event occurred. Conclusions Hematoporphyrin monomethyl ether photodynamic therapy is an effective and safe for management of facial port wine stains in the Sturge-Weber syndrome patients.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104955

Authors: Hongzhao Lei, Hongyu Zhang, Longlong Sun, Bin Sun, Changxian Dong

Institution: Henan Provincial People's Hospital

Language: English

Topic: Vascular Malformations and Hemangiomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610