Work

Effect and Mechanism of Photodynamic Therapy on Pyroptosis of Gastric Cancer Cells via PRKAA1

Year: 2025

Type: article

Abstract: The incidence and mortality rates of gastric cancer are high in our country, posing a significant threat to public health and imposing substantial economic burden and medical pressure. PDT (Photodynamic therapy) is still in the exploratory stage for treating gastric cancer. Although some progress has been made, demonstrating several irreplaceable advantages, there is still a need to improve its efficacy and study the specific mechanism of PDT-induced death in gastric cancer. PRKAA1 (protein kinase AMP-activated catalytic subunit α1), as a core factor in energy metabolism, plays a role in multiple biological processes involved in malignant tumor progression. This study aims to analyze the impact of PRKAA1 on PDT treatment for gastric cancer, explore the specific mechanism by which PDT promotes cell death through PRKAA1, and identify new targets and therapeutic strategies for treating this disease.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104886

Authors: Na Wang, Weiling He

Institution: Xiamen University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610