Work

Photodynamic Strategies for Combating Bacterial Biofilm-Associated Infections

Year: 2025

Type: article

Abstract: Significance Persistent and recurrent bacterial pharyngotonsillitis is a significant challenge, often linked to biofilm formation in tonsillar crypts. These biofilms contribute to antibiotic resistance, complicating treatment. Photodynamic Therapy (PDT) has shown promise in enhancing antibiotic effectiveness against planktonic bacteria, but its impact on biofilms requires further exploration. Approach This study investigates the effects of PDT using curcumin (CUR) as a photosensitizer on Staphylococcus aureus biofilms. The focus is on CUR’s ability to penetrate biofilm layers and the subsequent changes in biofilm reformation. Results CUR penetration was found to vary with biofilm formation time and complexity, significantly reducing biofilm recovery after PDT. PDT altered the biofilm’s structure and metabolism, improving CUR uptake. Conclusions PDT demonstrates the ability to disrupt biofilm integrity and hinder bacterial regrowth, offering potential as an adjunctive therapy for biofilm-associated infections.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104962

Authors: Kate Blanco, Vladislav Yakovlev, Vanderlei Bagnato

Institutions: Universidade de São Paulo, Texas A&M University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610