Work

Efficacy of ALA-PDT combined with the pretreatment of air jet metronidazole injection in the treatment of mild to moderate acne vulgaris

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Significance 5-aminolevulinic photodynamic therapy (ALA-PDT) is one of the important methods for the treatment of moderate to severe acne. This study explores the therapeutic efficacy of ALA-PDT combined with air jet metronidazole injection for mild to moderate acne vulgaris. Approach A total of 48 patients with mild to moderate acne vulgaris were randomly divided into treatment group (ALA-PDT combined with the pretreatment of air jet metronidazole injection) and control group (ALA-PDT alone). The efficacy index was assessed before and after the treatments. Results the treatment group had a significant curative effect (effective rate was 87.5% in the treatment group and 67.5% in the control group), and the onset time of effect was significantly earlier than that of the control group. Conclusions ALA-PDT combined with the pretreatment of metronidazole injection is safe and effective in the treatment of mild to moderate acne vulgaris with early onset and high patient satisfaction.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104901

Authors: Lin Liu, Na Wang, Ling Liu

Institution: Tang Du Hospital

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610