Work

Efficacy prediction model of Hematoporphyrin monomethyl ether photodynamic therapy for facial Port-wine stains

Year: 2025

Type: article

Abstract: Significance Hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) is a promising therapy for port-wine stains (PWS). However, the efficacy varies among individuals and cannot be accurately predicted. Approach Facial PWS patients who had undergone PDT from January 2019 to July 2023 were included. Logistic regression analysis was used to determine the efficacy influencing factors. The nomogram was used to score the efficacy influencing factors and construct a scoring model. Results A total of 863 patients were included. Age, PWS location, type of PWS, previous treatment history, PDT sessions, vascular and non-vascular features under dermoscopy were efficacy influencing factors of PDT in facial PWS. Based on these, a nomogram prediction model was constructed. The model's performance was good in terms of differentiation, calibration, and clinical utility. Conclusions A nomogram was developed to predict PDT efficacy in facial PWS. It provides dermatologists with an accurate PDT efficacy prediction tool for facial PWS.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104841

Authors: Jun Yang, Yuanbo Huang, Mingye Bi

Institutions: Wuxi People's Hospital, Nanjing Medical University

Language: English

Topic: Dermatologic Treatments and Research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610