Work

Exploration of Spectral Online Monitoring (SOM) Concepts for Interstitial PDT and Direct Light Therapy (DLT) on Inhomogeneous Tissue Phantoms

Year: 2025

Type: article

Abstract: Significance Photodynamic Therapy (PDT) has proven to provide unprecedented treatment results for many patients. However, similar approaches not requiring accumulation of a photosensitizer in the target tissue should be explored as new treatment options for diseases not susceptible to PDT. Approach Direct Light Therapy (DLT) will be explored as a treatment option for tumors that do not exhibit tumor-selective accumulation of a photosensitizer. DLT relies on direct optical excitation of intracellular oxygen to singlet oxygen at 1267 nm wavelength to induce phototoxic effects in tumor cells. Dosimetry and monitoring concepts for DLT were examined. Results Spectral online monitoring (SOM) established for interstitial PDT (iPDT) between cylindrical light diffusers was quantitatively investigated on inhomogeneous optical phantoms at 635 nm and 1267 nm wavelength. Conclusions For both wavelengths, SOM results can be quantitatively explained using a simple model based on light diffusion theory. This paves the way for transferring results from iPDT to DLT.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105153

Authors: Adrian Rühm, Krishna Prasad Subedi, Julian Schmidt, Daniel Pfaller, Maximilian Aumiller, Ronald Sroka

Institutions: LMU Klinikum, Ludwig-Maximilians-Universität München

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610