Work

Effect of the combination of diode laser ablation with photodynamic therapy for oral leukoplakia with epithelial dysplasia

Year: 2025

Type: article

Abstract: Significance Combining diode laser ablation with PDT may be one of the optimal choices for treating OLK with epithelial dysplasia. Approach Forty-one patients diagnosed with OLK with epithelial dysplasia were recruited in the study. All patients received diode laser ablation with PDT. The clinical treatment effect was recorded 1 month after the therapy, and every 3 months thereafter. Results All the patients responded to the combined therapy. The rates of complete and partial response were 61.0% (25/41) and 39.0% (16/41), respectively. Lesion size ≤ 200 mm2 was associated with complete response (p < 0.05). During the 12-month follow-up, recurrence was observed in 13 (31.0%) patients. The cumulative malignant transformation rate was 7.3% (3/41). Conclusions Diode laser ablation combined with PDT is an effective and high-efficiency treatment modality for OLK with epithelial dysplasia, particularly for lesion size ≤ 200 mm2. However, recurrence and malignant transformation still exist after therapy.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104840

Authors: Rui Lu, Bingjie Dong, Xiaojie Chen, Jing Zhang, Yaqin Tan, Gang Zhou

Institution: Wuhan University

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610