Work

Potential mechanisms of HPV E6/E7 gene regulation of host extracellular matrix composition and function

Year: 2025

Type: article

Abstract: The human papillomavirus (HPV) E6/E7 proteins are thought to be critical in its pathogenesis, and the extracellular matrix (ECM) is a class of complex spatial network structures whose function involves a variety of biological processes. Differentially expressed genes were detected by transcriptome sequencing in HPV type 11 E6/E7-transfected HaCaT cells, and their expression and changes in ECM components were verified at the cellular and condyloma acuminatum tissue levels by qPCR. A total of 16 common differential genes were identified, which were mainly involved in regulating the structure and function of ECM. The transfected cells showed decreased adhesion, increased migration, and proliferation. qPCR showed that 11 genes were down-regulated. Tissue level showed that the expression of seven genes and components of the ECM was reduced in wart tissues of patients with warts infected with various HPV types. These differential genes may be critical for the regulation of ECM components by HPV viruses.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104933

Authors: Rui Xu, Meinian Xu, Junpeng Li, Yu Chen, Changxing Li, Kang Zeng

Institutions: Nanfang Hospital, Southern Medical University, Dongguan People’s Hospital

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610