Work

Study of joint pharmacokinetics and pharmacodynamics of methylene blue and chlorin e6 in vivo on the mice tumor models

Year: 2025

Type: article

Abstract: Significance It is important to search new therapeutic approaches that will improve the effectiveness of tumor treatment. Approach The pharmacokinetics and pharmacodynamics of methylene blue (MB) and chlorin e6 in vivo on the mice tumor models were studied using spectroscopic methods. Results The combined use of MB and chlorin e6 allows to increase the efficiency of photodynamic therapy (PDT) due to two different mechanisms: a decrease in the rate of MB transition to colorless photoinactive leukomethylene blue and an increase in the photodynamic effect due to type I reactions (MB), complementing the photodynamic effect due to type II reactions (chlorin e6); an increase in tumor oxygenation during the transition of MB to colorless photoinactive leukomethylene blue and an increase in the photodynamic effect due to type II reactions (chlorin e6). Conclusions The combined use of MB and chlorin e6 allows to increase the efficiency of PDT.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104995

Authors: Daria Pominova, Anastasia Ryabova, Alexey Skobeltsin, Inessa Markova, Igor Romanishkin

Institutions: Russian Academy of Sciences, Prokhorov General Physics Institute, National Research Nuclear University MEPhI

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610