Work

Investigating application of PDT for Mucormycosis: A Novel Adjunctive Treatment for Deep-Seated Fungal Infections

Year: 2025

Type: article

Abstract: Significance Mucormycosis is a life-threatening, angio-invasive fungal infection with high morbidity and mortality. Standard treatments, including antifungal therapy and surgical debridement, often fail to achieve complete fungal eradication. This study explores photodynamic therapy (PDT) as a potential adjunctive treatment to enhance therapeutic outcomes. Approach We are evaluating the antifungal effects of three photosensitizers—methylene blue, curcumin, and indocyanine green—activated by a light source on ex vivo human skin samples inoculated with mucormycosis. These photosensitizers were selected for their distinct light absorption spectra and tissue penetration capabilities. Results Preliminary findings suggest PDT’s effectiveness in reducing fungal burden. Ongoing data collection will validate these outcomes and provide a comparison of the efficacy of each photosensitizer. Conclusion This study underscores the potential of PDT as an adjunctive treatment for mucormycosis, laying the foundation as a complementary strategy in clinical practice.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105080

Authors: AASHVI JOSHI, COLIN HOPPER

Institution: University College London

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610