Work

Pathological complete remission of an advanced gastric cancer patient after treatment with photodynamic therapy combined with chemotherapy, targeted therapy and immunotherapy: a case report and literature review

Year: 2025

Type: article

Abstract: Significance To investigate the efficacy of photodynamic therapy combined with chemotherapy, targeted therapy and immunotherapy in the conversion therapy of dMMR/MSI-H advanced gastric cancer to improve the prognosis of patients. Approach The clinical data of a patient with dMMR/MSI-H advanced gastric cancer admitted to our hospital were retrospectively analyzed, and the process of conversion therapy for this patient was described. Through images, laboratory examination and clinical evaluation of therapeutic effect. Results The successful conversion therapy using photodynamic therapy combined with chemotherapy, targeted therapy and immunotherapy in this patient created an opportunity for subsequent radical resection of gastric cancer. Conclusions Photodynamic therapy combined with chemotherapy, targeted therapy and immunotherapy is significantly effective in the conversion therapy of dMMR/MSI-H advanced gastric cancer, which has great clinical reference value.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105020

Authors: Huanuan Ma, Hao Chen

Institutions: Lanzhou University Second Hospital, Lanzhou University

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610